Neuroinflammatory tissue responses

Until recently, chemokines and their receptors were believed to have evolved solely for the purpose of recruiting and activating immune cells during inflammation. As the known roles for chemokines increased through studies of their eflfects on hematopoiesis and lymphopoiesis, it became clear that they are important in the development and homeostasis of almost all tissues. In the central nervous system (CNS), investigations of the chemokines responsible for leukocyte recruitment into the CNS during various neuroinflammatory diseases lead to additional discoveries regarding their... 

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