Neural endopeptidase inhibitor

Atrial Natriuretic Peptide Potentiator Diuretics. Neural endopeptidase inhibitors or atrial peptidase inhibitors are compounds that inhibit the enzyme (hat degrades ANP. resulting in higher plasma concemratioas, and longer duration of action, of ANP. The diuretic effects of this class... 

Table 4. Neural Endopeptidase (Atrial Peptidase) Inhibitors...

A limited amount of work was also conducted by the group of Schultz to investigate the potential of N-formyl hydroxylamine head group to inhibit HDAC. This bidentate chelating moiety was used successfully in inhibitors of angiotensin converting enzyme and neural endopeptidase, however, in the case of HDAC a 50-fold loss in activity was observed vdth this group (17a-c) [33]. 

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