Network of Glycerophospholipid Biosynthesis Pathways

The main difference between animals/plants and yeast is the PS synthesis pathway. In the former, PS species are synthesized from PC and PE species through serine exchange with choline and ethanolamine by PS synthase 1 and 2, respectively, in 

In bacteria, all the GPL synthesis pathways are through CDP-DAG. For example, PC species are synthesized through condensation of choline with CDP-DAG [25]. PE species are obtained after decarboxylation from PS species, which are synthesized through condensation of serine with CDP-DAG. However, both PC and PE classes are synthesized through condensation of CDP-choline (-ethanolamine) with DAG, respectively, in both animals/plants and yeast. Another difference present in bacteria compared to animals/plants and yeast is the biosynthesis of CL. In bacteria, CL species are synthesized through condensation between PG species, whereas in animals/plants and yeast, this class of lipids is obtained from condensation of PG with CDP-DAG. 

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