Netropsin, binding energy

The binding energy of the guanidinium ion is found to be higher by 2.9 kcals/mole than the one of the aminopyrrolidium ion. This difference agrees with the fact that netropsin binds better than anthelvencin to DNA but it is too small to account for the experimental difference in binding. 

Table 1. Absolute free energy of netropsin binding to [d(CGCGAATTGCGC)]2...

Dolenc, J. Oostenbrink, C. Koller, J. van Gunsteren, W.F., Molecular dynamics simulations and free energy calculations of netropsin and distamycin binding to an AAAAA DNA binding site, Nucl. Acids Res. 2005, 33, 725-733. 

Table 2. Free energy difference (kcal/mol) in binding of netropsin to d(GC)6 d(GC)6 versus that to d(IC)6 d(IC)6 ...

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