Nephthea brassica

Blackman, A.J., B.F. Bowden, J.C. Coll, B. Frick, M. Mahendran, and S.J. Mitchell Studies of Australian Soft Corals. XXIX Several New Cembranoid Diterpenes from Nephthea brassica 2in6. Related Diterpenes from a Sarcophyton Species. Aust. J. Chem. 35, 1873 (1982). 

Nephthea brassica Terpenoids (di- and sesquiterpenes) Crude extract brassicolene brassicolide brassicolide acetate (-)-4a-0-Acetyl-selin-11-en ( )-selin-11-em-4a-ol nephthenol cembrene A epoxycembrene A and (-)-P-elemene Cytotoxicity against tumor cells [87,88]... 

Brassicolene is a bicyclo[12,l,0]pentadecane also related to cembrane. Discovered in 2000 in the alcyonacean Nephthea brassica, this cytotoxic derivative is the first representative of this new carbon skeleton with a cyclo-propene. Its cytotoxicity in vitro against A-549 Itmg cancer cells and P-388 leukemia cells is, respectively, ED50 3.62 and ED50 0.86p.gml (Duh et al., 2000c). Microclavatin, isolated from Sinularia microclavata of Chinese origin, is another example of a bicyclo[12,l,0]pentadecane, but with a cyclopropane. 

Brassicolene Nephthea brassica Duh, Wang, and Weng, 2000c... 

Duh, C.-Y, Wang, S.-K., and Weng, Y.-L. (2000c) Brassicolene, a novel cytotoxic diterpenoid from ftie Formosan soft coral Nephthea brassica. Tetrahedron Lett., 41, 1401-1403. 

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