Propofol Neostigmine

Reduction of secretions and vagal reflexes Muscarinic antagonists, usually hyoscine, are used to prevent salivation and bronchial secretions and, more importantly, to proteci the heart from arrhythmias, particularly bradycardia caused by halothane, propofol, suxamethonium and neostigmine. Hyoscine is also iiniiemeiic and produces some amnesia. 

Inhalation anaesthetics may impair the efficacy of anticholinesterases in reversing neuromuscular blockade. Propofol does not affect the reversal of rocuronium block by neostigmine. Physostigmine pre-treatment increased propofol requirements by 20% in one study. 

Reid JE, Breslin DS, Mirakhur RK, Hayes AH. Neostigmine antagonism of rocuronium block during anesthesia with sevoflurane, isoflurane or propofol. Can JAnaesth (2001) 48, 351-5. 

Noninterfering alfentanil, aprotinin, atropine, bupivacaine, chlorpromazine, dalteparin, dexamethasone, diazepam, dopamine, droperidol, etomidate, fentanyl, furosemide, gallamine, haloperidol, midazolam, morphine, neostigmine, nitroglycerin, nitroprusside, oxytocin, pancuronium, pentobarbital, phenylephrine, phenytoin, pipecuronium, piperacillin, promethazine, propofol, ranitidine, succinylcholine, sufentanil, terbutaline, thiopental, vecuronium, verapamil... 

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