Neopentyl acetate, hydrolysis

No rearranged products were formed during the formation and hydrolysis of neopentyl acetate 4 or a-methylallyl acetate.5 If free carbonium ions had been obtained by an alkyl-oxygen fission, we should expect rearrangement products (see pp. 44, 57). 

Birch reduction of the norgetrel intermediate 5 oil owed by hydrolysis of the enol ether gives the enone oxidation of the alcohol at 17 leads to dione 7. Fermentation of that intermediate in the presence of the mold PeniciIlium raistricky serves to introduce a hydroxyl group at the 15 position W. Acetal formation with neopentyl glycol affords the protected ketone which consists of a mixture of the A and A isomers (2 ) hindrance at position 17 ensures selective reaction of the 3 ketone. The... 

Here we further examine the suitability of QM-SCRF methods in two chemical reactions the base-catalysed hydrolysis of methyl acetate in water, and the steric retardation of Sn2 reactions of chloride with ethyl and neopentyl chlorides in water. In the two cases the influence of the solvent is examined by using the MST version of the PCM model (see ref. [85] for a detailed description). 

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