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Nelfinavir structure-based design

Nelfinavir. Using structure-based design in conjunction with predicted oral pharmacokinetics, NFV was identified and found to have potent inhibition of HIV-1 in vitro with an IC50 in the 2nM range (Kaldor et al. 1997). Clinical trials of NFV revealed robust and sustained reductions in HIV-1 RNA with over half of all subjects attaining a persistent 1.6 logxo reduction at 12 months, in conjunction with a mean increase in CD4 cells of 180-200 per mm (Markowitz et al. 1998). In subjects... [Pg.90]

See other pages where Nelfinavir structure-based design is mentioned: [Pg.381]    [Pg.516]    [Pg.274]    [Pg.110]    [Pg.110]    [Pg.942]    [Pg.542]    [Pg.211]    [Pg.119]    [Pg.18]    [Pg.295]   
See also in sourсe #XX -- [ Pg.440 , Pg.442 ]

See also in sourсe #XX -- [ Pg.440 , Pg.442 ]



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Structure based design

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