Neighboring exclusion

Base Proton Complexation Shifts The complexation shifts of certain nucleic acid base resonances of poly(dA-dT) on formation of the daunomycin neighbor exclusion complex reflect the shielding contribution due to the anthracycline ring less the contribution from one neighboring base pair which is displaced following intercalation. Thus, the adenosine H-2 resonance remains unperturbed (Figure 27) while the thymidine exchangeable H-3 proton... 

Veal et al. suggested that bisintercalation of SDM may violate the neighbor exclusion principle models of this type could be built in the same way as above, starting with the model DNA structure proposed by Rao and Kollman. ... 

DNA-Dye system. Choice of convenient expressions for describing binding equilibria and kinetics depends on the model adopted for the nature of the binding site. Two kinds of expressions were proposed one is the Scatchard description and the other is the neighbor-exclusion model. In the present work, the former expression was adopted in order to make easy the comparison of the data between native and denatured DNA,... 

Fig. 3 Binding mode of bisintercalators depending on the length of the alkyl chain between the intercalating moieties (A Monointercalation. B Bisintercalation with violation of neighbor-exclusion principle. C Bisintercalation)...

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