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Negishi cross-coupling acid chlorides

The regioselective C-5 lithiation of 2-TST (1) followed by transmetalation with zinc chloride and palladium(0)-catalyzed Negishi cross-coupling was employed to prepare 5-aryl- and 5-heteroaryl-substituted thiazoles (20) in a one-pot procedure (eq 29). The lithiation and transmetalation were performed in diethyl ether because of the instability of 5-lithio-2-trimethyl-silylthiazole in THF at — 78 °C. The 2-trimethylsilyl group of the cross-coupled products was cleaved quantitatively under acidic conditions. [Pg.717]

See other pages where Negishi cross-coupling acid chlorides is mentioned: [Pg.81]    [Pg.188]    [Pg.451]    [Pg.20]    [Pg.101]    [Pg.101]    [Pg.77]    [Pg.91]    [Pg.60]    [Pg.318]    [Pg.32]    [Pg.316]    [Pg.252]    [Pg.325]    [Pg.29]    [Pg.30]    [Pg.361]    [Pg.370]    [Pg.38]    [Pg.117]    [Pg.252]    [Pg.387]    [Pg.467]    [Pg.738]    [Pg.12]    [Pg.21]    [Pg.34]    [Pg.142]   
See also in sourсe #XX -- [ Pg.39 ]



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Chlorides cross-coupling

Coupling chloride

Negishi

Negishi coupling

Negishi cross-coupling

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