Nebulised drug delivery

Knoch, M., and Keller, M. (2005), The customised electronic nebuliser A new category of liquid aerosol drug delivery systems, Expert Opin. Drug Deliv., 2, 377-390. 

Kwok, P.C.L. Chan, H.-K. Measurement of electrostatic charge of nebulised aqueous droplets with the electrical 79. low pressure impactor. In Respiratory Drug Delivery IX ... 

Stangl, R. Luangkhot, N. Liening-Ewert, R. Jahn, D. Characterising the first prototype of a vibrating membrane nebuliser. In Respiratory Drug Delivery VII Dalby, R.N., Byron, P.R., Farr, S.J., Peart, J., Eds. Interpharm Press, 2000 455 58. 

MacCaUion ONM, Taylor KMG, Bridges PA, Thomas M, Taylor AJ. Jet nebulisers for pulmonary drug delivery. Int J Pharm 1996 130 1-11. 

Unlike most other drug delivery systems, those in the respiratory area can have a major influence on physician/patient acceptance. A wide range of devices are available in the three main categories of dry powder inhalers (DPIs) and metered dose inhalers (MDIs), i.e., pressurised aerosols and nebulisers. The preferred type of inhaler varies considerably between countries (e.g., DPIs in Scandinavia and MDIs in the United States), and between patient groups (e.g., nebulisers for paediatrics). 

Devadason 8G, Everard ML, Linto JM, Le 8ouef PN. Comparison of drug delivery from conventional versus Venturi nebulizers. Eur Respir J 1997 10 2479-2483. Wilson D, Bumiston M, Moya E, Parkin A, 8mye 8, Robinson P, et al. Improvement of nebulised antibiotic delivery in cystic fibrosis. Arch Dis Child 1999 80 348-352. 

Devadason SG, Everard ML, Linto JM, Le Souef PN. Comparison of drug delivery from conventional versus Venturi nebulisers. Eur Respir J 1997 10 2479-2483. 

Lass, J. S., Sant, A., and Knoch, M. 2006. New advances in aerosolised drug delivery vibrating membrane nebuliser technology, Exp. Op. Drug Del. 3 693-702. 

Everard ML, Clark AR, Milner AD. Drug delivery from jet nebulisers. Arch Dis Child 1992 67 586-591. 

Typical Class I devices include powder delivery systems to the lungs such as the Spinhaler, Rotahaler, Diskhaler, spacers which are used in conjunction with a drug and are part of a drug submission. Typical Class Ha devices include power operated nebuliser systems which are usually sold separate to the drug. 

Elhissi AM A, Taylor KMG. Delivery of liposomes generated from proUposomes using air-jet, ultrasonic, and vibrating-mesh nebulisers. J Drug Del Sci Tech 2005 15 261-5. 

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