Natural oligopeptides

Biomimetic syntheses of isodithyrosine natural products, and an approach to chemistry and molecular recognition of secoaglucovancomycin and related oligopeptides 97YGK1029. 

Welker, M. Brunke, M. Preussel, K. Lippert, I. von Dohren, H. Diversity and distribution of microcystis (Cyanobacteria) oligopeptide chemotypes from natural communities studied by single-colony mass spectrometry. Microbiology 2004,150, 1785-1796. 

Fei, Y. J., et al. Expression cloning of a mammalian proton-coupled oligopeptide transporter. Nature 1994, 368, 563-566. 

DKPs, and 2,6-DKPs can be distinguished on the basis of intramolecular C-N cyclization, tandem reactions, and synthetic methods used. 2,3-DKPs have been used in medicinal chemistry and are found in natural products such as antibiotics (piperacillin), cefoperazone, and bicyclomycin. 2,5-DKPs are common namrally occurring peptide derivatives and are frequently generated as unwanted by-products in the synthesis of oligopeptides. " ... 

All cyclosporines (A,B,C,. .. U,V,W), are oligopeptides containing 11 amino acids closed in a cyclic form. All of these are known amino acids except the first, which sometimes has not been isolated from natural sources. All of them are L-amino acids except for the amino acids in positions 3 and 8. Because of all of the hydrogen bonds, the structure of cyclosporine is quite rigid. Cyclosporines (A,B,C,. .. U,V,W) only differ in the second amino acid. 

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