Natural killer cell defined

Baume D-M, Robertson MJ, Levine H, Manley TJ, Schow PW, Ritz J Differential responses to interleukin-2 define functionally distinct subsets of human natural killer cells. Fur J Immunol 1992 22 1-6. 

Another approach to induce a GVT effect in patients who relapse following HSCT is to administer a cytokine posttransplant with immunomodulatory activity, such as interleukin-2 (IL-2)." Some beneficial effects have been observed with the use of IL-2 with respect to effects on natural killer cells and other important antitumor immune responses. Toxicities have been tolerable in most patients but can be serious and life-threatening. Studies are necessary to define the role of these cytokines in prolonging relapse-free survival after HSCT. 

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