Narcissus alkaloids

Narcissus alkaloid structures. Haemanthamine and Crinine types. 

Narcissus alkaloid structures. Narciclasine and Montanine types. 

Only NMR, NMR, and mass spectrometry, the three most important spectroscopic methods for the Amaryllidaceae alkaloids, will be treated here. A list of names of the different Narcissus alkaloids, their physical and spectroscopic properties, as well as literature is given in Table 3. With respect to the spectroscopic results, the most recent data about the mentioned alkaloids are provided, even when isolation was made from species of genera other than Narcissus. 

Table 6 shows the different pharmacological and/or biological properties exhibited by the alkaloids from the genus Narcissus L., but only some of the activities of a reduced number of Narcissus alkaloids are known. The most extensively studied effect is that of non-specific inhibition, e.g. antitumour, antimitotic, suppression of development of splenomegaly and increase in number of nucleated blood cells. The relationship of chemical structure and biological activity of these alkaloids is largely unknown (236), and further... 

The alkaloids of the homolycorine series, formed by a restructuring of lycorine-type alkaloids, are absent from some tribes of the Amaryllidaceae, such as the Amaryllideae or Hemantheae (44). For that reason, the presence of these alkaloids is a distinctive feature of the Narcisseae tribe. Moreover, all the Narcissus alkaloids of the homolycorine series display a B/C ring junction with a cis stereochemistry. An exceptional homolycorine-type alkaloid is dubiusine (33), which has an unusual hydroxybutyryl substituent (72). 

Narcissus Alkaloid Structures. Narciclasine and Montanine Types. 

Occurrence of Narcissus Alkaloids in Wild Species and Intersectional Hybrids. 

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