Heart failure naproxen

Two elderly women with congestive heart failure did not respond to treatment with furosemide and digoxin until the naproxen they were taking was withdrawn. A single-dose study in patients with heart failure found that the volume of urine excreted in response to furosemide was reduced about 50% by naproxen. 3 jjj placebo-controlled study, 6 patients with cirrhosis and ascites were given a single 40-mg intravenous dose of furosemide before and after naproxen 500 mg twice daily for 5 doses. It was found that this short-term use of naproxen reduced the glomerular filtration rate and the natriuretic and diuretic effects of furosemide. ... 

ANTI-INFLVMMATORY AND ANTIPYRETIC ANALGESICS AND DRUGS USED IN GOUT TABLE 2 Effects of COX-2 Selective Inhibitors, Naproxen, Diclofenac and Ibuprofen on Major Vascular Events, Heart Failure Hospitalization, All-Cause Mortality and Upper Gastrointestinal Complications ... 

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