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Napieralski, Bernard

Bischler, A. Napieralski, B. Ber. 1893, 26,1903-1908. Augustus Bischler discovered the Bischler-Napieralski reaction while studying alkaloids at Basel Chemical Works, Switzerland with his coworker, B. Napieralski. Bernard Napieralski was affiliated with the University of Zurich. [Pg.57]

The synthesis of 3,4-dihydroisoquinolines via intramolecular reactions of phenethyl amides was first reported by August Bischler and Bernard Napieralski in 1893. The authors described the conversion of A-acyl phenethylamide (1, R = Me) and A-benzoyl phenethylamide (1, R = Ph) to 1-methyl-3,4-dihydroisoquinoline (2, R = Me) and 1-phenyl-3,4-dihydroisoquinoline (2, R = Ph), respectively, in the presence of P2O5. This reaction has subsequently proven to be one of the most general methods ever developed for the synthesis of dihydroisoquinolines. [Pg.376]

Reaction of phenylethyl amides with a dehydrating agent, such as P2O5 or POCI3, was first described by August Bischler and Bernard Napieralski in 1893 to afford 3,4-dihydro-isoquinolines in good yields. [Pg.513]

In 1893, the Bischler-Napieralski (B-N) reaction was initially reported by August Bischler and Bernard Napieralski in association with BASEL chemical works and the University of Zurich, Switzerland,... [Pg.183]


See other pages where Napieralski, Bernard is mentioned: [Pg.183]   
See also in sourсe #XX -- [ Pg.513 ]




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