2.7- Naphthyridinecarboxylic acids reactions

Naphthyridinecarboxylic acids undergo the usual reactions, as illustrated in the following examples. 

These esters have been reduced to hydroxymethyl-1,8-naphthyridines (see Section 25.1.1) and hydrolyzed to 1,8-naphthyridinecarboxylic acids (see Section 28.1.1). Other reactions are illustrated by the following examples. 

The reaction of naphthyridinecarboxylic acids 281 with guanidine in the presence of carbonyldiimidazole in anhydrous THF results in hetaroylguanidines 282, which can be used for the therapy of heart diseases, for surgical operations and organ transplantation, for the diagnostics and treatment of hypertension and proliferative diseases (1986GEP3508816). 

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