Naphthyridinecarboxamides, Carbonitriles, Carbaldehydes, and Ketones

Note The reduction of these esters to hydroxymethyl-1,5-naphthridines (Section 4.1.1) and their hydrolysis to carboxylic acids (Section 7.1) have been exemplified already the nuclear dehydrogenation of a dihydro ester is seen in the following example. 

Ethyl 6-p-fluorophenoxy-l, 4-di hydro- (19) gave ethyl 6-p-fluorophenoxy-1, 5-naphthyridine-3-carboxylate (20) (substrate, ACMe KMnCVACMel drop-wise 97%).967 

The scarce information about these derivatives is a summarized in the following paragraphs. 

These amides have been made by primary synthesis (see Chapter 1) or by direct or indirect aminolysis of corresponding carboxylic acids (see Section 7.1). No reactions appear to have been described. 

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