Naphthoquinones Nicotine

Several protocols using multi-component reactions to prepare multisubstituted furans were reported. One procedure was that using acetylenedicarboxylate, isocyanides, triphenylphosphine and an aromatic carboxylic acid <07SL1610>. The others include the reaction of acetylenedicarboxylate, isocyanides and nicotinic acid <07S2637>, of dibenzoylacetylene, amines and diketene <07T8083>, of alkyl isocyanides, aromatic aldehydes and 3-cyanoacetyl indoles <07TL8987>, and of naphthoquinone, isocyanides and aldehydes <07T10269>. 

DESI cocaine, raclopride, nicotine, cotinine (metabolite of nicotine), ketamine, norketamine, clozapine (antipsychotic), propafenone, verapamil, Sutent, reserpine, paracetamol, naphthoquinone, propranolol, dopamine, VitB12, caffeine, etc. 75, Liu et al. (2007), Law (2010), Ostman et al. (2006), Nordstrom et al. (2006)... 

Certain organic products can inhibit the action of diluted hydrochloric acid. Most of them are amines, such as anihne, dibutylamine, thiourea, naphthoquinone, acridine, nicotine. Their effectiveness depends on the acid concentration and on the temperature. Their lifetime is limited. Preliminary tests are recommended in order to determine the performance of an inhibitor in a given medium. 

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