Nanostructured scaffolds as controlled release matrices

Electrospun nanostructured scaffolds have been intensively investigated as 3-D scaffolds for bone engineering. The principle of electrospinning is to apply high voltage on polymer solution or melt to overcome its surface tension and draw the 

Heparin-conjugated PLGA scaffolds have been fabricated though techniques such as gas-foaming/salt-leaching and have been used to sustain drug delivery of growth factors like BMP-2 to enhance bone formation [92,93]. 

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