Naloxone 6-methylene

Methylene- Oenothera biennis (Onagraceae), [Naloxone-reversed... 

DL-methionine. methylthioninium chloride (methylene blue) naloxone penicillamine potassium ferric hexacyanoferrate(II). 2Hj O (Prussian blue)... 

B. Nalmefene, an injectable methylene analog of naltrexone, was approved In 1995. It is 4 times more potent than naloxone at mu receptors and slightly more potent at kappa receptors. It has a longer elimination half-life (ranging from approximately 8 to 11 hours after IV dosing), and has a duration of action of 1 hours (see Table 111-8). The prolonged effects of nalmefene are related to the slow dissociation from the opioid receptor, which Is not reflected in the AUC plasma curve. 

---