Nifedipine Nafcillin

Noninterfering acetaminophen, N-acetylprocainamide, amikacin, amitriptyline, amlodi-pine, carbamazepine, cefotaxime, ceftazidime, chloramphenicol, ciprofloxacin, cisapride, clindamycin, clonidine, codeine, cyclosporine, digoxin, diphenhydramine, disopyramide, ethosuximide, fluconazole, gentamicin, gentamicin, heparin, labetalol, levothyroxine, li-docaine, lithium, methotrexate, metronidazole, minoxidil, nafcillin, nifedipine, phenobar-bital, phenobarbital, phenytoin, phenytoin, primidone, procainamide, propranolol, quini-dine, ranitidine, salicylic acid, theophylline, tobramycin, tobramycin, valproic acid, warfarin... 

Nifedipine increases the absorption of amoxicillin from the gut but this is unlikely to be clinically important. Nafcillin increases the clearance of nifedipine, but the clinical significance of this is unclear. 

In a randomised, placebo-controlled study, 9 healthy subjects were given a single 10-mg nifedipine capsule after a 5-day course of nafcillin 500 mg four times daily. The nifedipine AUC was decreased by 63% and the clearance was increased by 145%, but the effect of these changes on nifedipine pharmacodynamics was not assessed. It was suggested that nafcillin is an inducer of cytochrome P450 isoenzymes, and increased the metabolism of nifedipine. The clinical significance of these changes is unclear. 

Lang CC, Jamal SK, Mohamed Z, Mustafa MR, Mustafa AM, Lee TC Evidence of an interaction between nifedipine and nafcillin in humans. BrJ Clin Pharmacol (2003) 55, 588-90. 

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See also in sourсe #XX -- [ ]

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