NADPH oxidase gp91 -phox

Figure 14.8 Phylogenetic tree of the gp91 phox subunit of NADPH oxidase (Nox), by courtesy of Dr. D. Lambeth, Pathology, Emory University, USA.

Archer SL, Reeve HL, Michelakis E, Puttagimta L, Waite R, Nelson DP, Dinauer MC, Weir EK. O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase. Proc Natl Acad Sci USA 1999 96 7944-7949. 

Figure 12 CGD mice lack the gp91 phox subunit of NADPH oxidase, (a) Immunohis-tochemistry (above) and immunoblotting (below, note the lower molecular weight is common in mice) experiments show that CGD mice lack the gp91 phox subunit of the en2yme, compared to wild mice (darker stain). Expression of p22 phox is similar in the CGD versus the wild mice. Note that in the CGD mice, the subunit is absent from the PA and alveolar (A) epithelial cells as well as from phagocytes (arrows). (From Ref. 99.)...

---