NADPH complex

Matthews DA, Alden RA, Bolin JT, Filman DJ, Freer ST, Hamlin R, Hoi WG, Kisliuk RL, Pastore EJ, Plante FT, Xuong N, Kraut J. Dihydrofolate reductase from Lactobacillus casei. X-ray structure of the enzyme methotrexate-NADPH complex. J Biol Chem 1978 253 6946-54. 

The early kinetic studies on glutathione reductase did not include investigation of product inhibition, so vital to a proper interpretation of kinetic data in the elucidation of the mechanism 247, 248). In the one case where product inhibition patterns were observed, they were not interpreted by more recent kinetic theory 40). Subsequent kinetic analyses see below), in which product inhibition patterns have been obtained, were either completed prior to the discovery of the EH2-NADPH complex... 

Boehr DD, McElheny D, Dyson HJ, Wright PE. Substrate-specific us-ms time-scale motions in the E. coli dihydrofolate reductase NADPH complex. FASEB J. 2005 19 A846-A847. 

DiFranco and Iwatsubo 323) observed that two distinct E-NADPH complexes, one weakly and the other strongly fluorescent, are observed... 

Figure 5.20. The high-field region of the 500 MHz H2D RELAY spectrum of the dihydrofolate reductase-trimethoprim-NADPH complex. The cross-peaks defining the spin system of valine (Val )...

Dihydrofolate Reductase from Lactobacillus casei X-Ray Structure of the Enzyme Methotrexate.NADPH Complex. 

Kisliuk, E. J. Pastore, L. T. Plante, N. Xuong, and J. Kraut,/. Biol. Chem., 253, 6946-6954 (1978). Dihydrofolate Reductase from Lactobacillus casei. X-Ray Structure of the Enzyme Methotrexate-NADPH Complex. 

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