Nabumetone dosage

NABUMETONE Recommended starting dose is 1,000 mg as a single dose with or without food. Some patients may obtain more symptomatic relief from 1,500 to 2,000 mg/day. Nabumetone can be given either once or twice/day. Dosages greater than 2,000 mg/day have not been studied. 

Its properties are very similar to those of other NSAIDs, though it may be less damaging to the stomach than some other NSAIDs when given at a dosage of 1000 mg/d. Unfortunately, higher dosages (eg, 1500-2000 mg/d) are often needed, and this is a very expensive NSAID. Like naproxen, nabumetone has been reported to cause pseudoporphyria and photosensitivity in some patients. Other adverse effects mirror those of other NSAIDs. 

There is little evidence to support clinically important differences with regard to the frequency of ulcers and upper GI complications among most available nonaspirin, nonselective NSAIDs (see Table 33-3) when used in equipotent anti-inflammatory dosages. However, the nonacetylated salicylates (e.g., salsalate) and newer NSAIDs (e.g., etodolac, nabumetone, and meloxicam) may be associated with a decreased incidence of GI toxicity. NSAIDs that selectively inhibit cyclooxygenase-2 (COX-2) decrease the incidence of gastroduodenal ulcers and related GI complications when compared to the nonselective NSAIDs. The use of buffered or enteric-coated aspirin confers no added protection from ulcer or GI complications. ... 

Nabumetone is indicated for the acute and chronic treatment of the signs and symptoms of osteoarthritis and rheumatoid arthritis. The recommended starting dosage is 1,000 mg as a singie dose with or without food. More symptomatic reiief of severe or persistent symp-toms may be obtained at doses of 1,500 or 2,000 mg/day. 

Sane, R.T. Patel, M.K. Kulkarni, U.D. Tirodkar, V.B. Application of different anal) tical techniques for the quantitation of nabumetone from its dosage form. Indian Drugs 1993, 30 (9), 468 72. 

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