N- thiourea

On reaction of the S/Z-mixture 746 with benzylamine in the presence of CS2, the cyclic thiocarbonates 757 and 758 are formed by attack of benzylammo-nium thiocarbonate on 747, N,N -thiourea 759 is also formed [236] (Scheme 5.81). 

Xue, M. Long, B. H. Eairchild, C. Johnston, K. Rose, W. C. Kadow, J. E Vyas, D. M. Chen, S.-H. Structure-activity relationship study at the 3 -N position of paclitaxel. Part 2 s3mthesis and biological evaluation of 3 -N-thiourea- and 3 -thiocarbamate-bearing paclitaxel analogues. Bioorg. Med. Chem. Lett., 2000, 10 1327-1331. 

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