N-Monoalkylation s. Amines

N-Monoalkylation s. Amines, sec., from amines, prim. Monochioromethyl ether, chloromethylation with — 11, 844... 

Figure 15 Examples of artificial collagen model peptide knots, (a) Regioselective artificial cystine knot, (b) dilysine scaffold,(c) c/s,c/s-1,3,5-trimethylcyclohexane-1,3,5-tricarboxylic acid Kemp tri acid , (d) TREN-(suc-OH)3, (Tris(2-aminoethyl)amine) succinic acid, (e) Fe + [2,2 -bipyridyl-peptide]3, " (f) monoalkyl chains, " (g) Boc-/3-Ala-TRIS-(OH)3 knot, and (h) N-terminal GFGEEG link. ...

Figure 10.25 Twenty-nine specific toxicophores for mutagenicity as identified by Kazius el al. (Kazius, J-, et al. Derivation and validation of toxicophores for mutagenicity prediction. J. Med. Chem. 2005, 48, 312-320.) (A) Specific aromatic nitro, (B) specific aromatic amine, (C) aromatic nitroso, (D) alkyl nitrite, (E) nitrosamine, (F) epoxide, (G) aziridine, (H) azide, (I) diazo, (J) triazene, (K) aromatic azo, (L) unsubstituted heteroatom-bonded heteroatom, (M) aryl hydroxylamine, (N) alkyl halide, (O) acyl halide, (P) N- or 5-mustard, (Q) polycyclic aromatics, (R) bay-region, (S) K-region, (T) sulphonate-bonded C, (U) unsaturated aldehyde, (V) alkyl A-nitro, (W) diazonium, (X) p-propiolactone, (Y) unsubstituted a,p unsaturated alkoxy, (Z) l-aryl-2-monoalkyl hydrazine, (AA) aromatic methylamine, (AB) aryl hydroxylamine ester, and (AC) polycyclic planar system.

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