N-ethyl-3,4-methylenedioxyamphetamine

Boja, J.W., and Schechter, M.D. Behavioral effects of N-ethyl-3,4-methylenedioxyamphetamine (MDE Eve ). Pharmacol Biochem Behav 28 153-156, 1987. 

Gold, L.H. Koob, G.F. and Geyer, M.A. Stimulant and hallucinogenic behavioral profiles of 3,4-methylenedioxymethamphetamine (MDMA) and N-ethyl-3,4-methylenedioxyamphetamine (MDE) in rats. J Pharmacol Exp Ther 247 547-555, 1988. 

Mancinelli and colleagues (1999) reported the simultaneous determination of 3-4-methylenedioxymethamphetamine (MDMA), N-ethyl-3,4-methylenedioxyamphetamine (MDEA), methylenedioxyamphetamine (MDA), and N-methyl-l-(l,3-benzdioxol-5-yl)-2-butamine (MBDB) by RP-HPLC with fluorometric detection. The method required a 100 pi sample volume of serum, urine, or saliva separation was achieved on a LiChrospher lOORP-18 analytical column using an acetonitrile/water mobile phase (pH 11.4) set at a flow rate of 1 ml/min. The LLOQ and LLOD were 50 and 10 ng/ml respectively. 

N-formyl-3,4-methylenedioxyamphetamine. An alternate process for the synthesis of this amide involved holding at reflux for 16 h a solution of 10 g of MDA as the free base in 20 mL fresh ethyl formate. Removal of the volatiles yielded an oil that set up to white crystals, weighing 7.8 g. 

Figure 4 Typicai gas chromatographic impurity profiies of different MDMA sampies. The big peak at retention time 12.2 min (after peak no. 12) corresponds to MDMA. Peaks 7, 3,4-meth-ylenedioxy-A/-melhyibenzyiamine 10, 3,4-methyienedioxyphenyi-2-propanone 12, 3,4-methyienedioxy-phenyi-2-propanoi 16, /V-ethyl-3,4-methyienedioxyamphetamine 17, A/,A/-dimethyi-3,4-methylenedioxyamphetamine 18, 1-(1,2-dimethyi-1-azacyciop-ropyl)methyl-3,4-methylenedioxybenzene 21, caffeine 24, palmitic acid 28, stearic acid. (Reproduced with permission from Palhol F, Boyer S, Naulet N, and Chabrillat M (2002) Impurity profiling of seized MDMA tablets by capillary gas chromatography. Analytical and Bioanalytical Chemistry 374 274-281 Springer-Verlag.)...

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