Myosin pharmacomechanical coupling

Somlyo AP, Somlyo AV 2000 Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol 522 177—185 Somlyo AP, Devine CE, Somlyo AV, N orth SR 1971 Sarcoplasmicreticulumand the temperature-dependent contraction of smooth muscle in calcium-free solutions. J Cell Biol 51 722—741 Somlyo AP, Walker JW, Goldman YE et al 1988 Inositol trisphosphate, calcium and muscle contraction. Philos Trans R Soc Lond B Biol Sci 320 399 114 Somlyo AP, Wu X, Walker LA, Somlyo AV 1999 Pharmacomechanical coupling the role of calcium, G-proteins, kinases and phosphatases. Rev Physiol Biochem Pharmacol 134 201-234... 

Pharmacomechanical coupling was primarily studied by measuring [Ca +J and myosin regulatory light chain phosphorylation in intact and skinned smooth muscle. Several groups found that stimuli increased... 

Modulation of myosin phosphorylation independent of changes in [Ca2+]j is another form of pharmacomechanical coupling. 

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