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Myoglobin helical content

Using the method of Prob. 4.10 the helical content of myoglobin can be calculated at both pH values, if we assume the presence of a-helical and disordered regions only. At pH 6.0, the helical content is 79 percent. However, at pH 2.0 the helical content is only 7 percent. We may conclude, then, that at low pH, the protein has lost its a-helical conformation i.e., it has been denatured. [Pg.104]

Although we must anticipate the discussion of optical rotatory dispersion as applied to proteins, it is relevant to mention here the ultraviolet measurements upon myoglobin which have already been described in connection with the issue of helical sense (see Section III, D). The agreement of these measurements upon myoglobin in solution with helical content in the crys-... [Pg.483]

For proteins with significant helical content it is possible to show that larger-scale displacements involve rigid-body motions of the helices. Two such proteins for which molecular dynamics simulations have been analyzed in terms of helix motions are the C-terminal fragment of the L7/L12 ribosomal protein of E. coli229 and myoglobin.230... [Pg.117]

The compact core of lysozyme consists of three antiparallel ]8-structures, e.g. the section 41-48 is H—bonded to the 54—49 section, which in turn is partly H—bonded to the 58-61 section [50-52]. In myoglobin, wliich contains practically no jS-structure, rigidity is provided by its high helical content ( 80%). The helical segments are held together by occasional H—bonds (for example Tyrosine H 22 with Isolencine FG 5) or are bound to the heme group [53]. Many other examples could be given. [Pg.360]

The most decisive support for this contention has proceeded from the X-ray study of crystalline sperm whale myoglobin, which, as Kendrew has demonstrated (Kendrew et al., 1960, 1961), contains 118 of its 153 residues, that is, 77 %, in right-handed a-helices. The side chains of L-amino acids in a right-handed helix project in a direction opposite to that of carbonyl groups hydrogen-bonded into the helix, an orientation that is in fact... [Pg.452]


See other pages where Myoglobin helical content is mentioned: [Pg.436]    [Pg.26]    [Pg.224]    [Pg.271]    [Pg.28]    [Pg.453]    [Pg.453]    [Pg.454]    [Pg.454]    [Pg.455]    [Pg.455]    [Pg.466]    [Pg.484]    [Pg.504]    [Pg.512]    [Pg.482]    [Pg.174]    [Pg.185]    [Pg.556]    [Pg.273]    [Pg.250]    [Pg.83]    [Pg.93]    [Pg.516]    [Pg.44]    [Pg.77]    [Pg.58]    [Pg.206]    [Pg.450]   
See also in sourсe #XX -- [ Pg.28 , Pg.333 ]




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Myoglobin

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