Mylia verrucosa

A curious diterpenoid isocyanide (174) has been obtained from the marine sponge Hymeniacidon amphilecta and its structure established by X-ray analysis. Divarol acetate (175), which is related to the dolatriols, has been obtained from some marine Dolabella species. Two further trinervitene diterpenoids (176), the 2a,3a- and 2a,3/8-diols, have been isolated from the frontal glands of the termite Nasutitermes costalis. The verrucosane skeleton has been assigned to some further diterpenoids from the liverwort Mylia verrucosa. Three more... 

The dialdehyde isosacculatal, previously isolated from the liverwort Tri-chocoleopsis sacculata, has also been found in another member of the Hepati-cae, Pellia endiviaefolia. Extensive chemical degradation based on opening of the cyclopropane ring and cleavage of rings a and b has led to the unusual structure (125) for 2,9-dihydroxyverrucosane, which was found in another liverwort, Mylia verrucosa. 

Hayashi, S., A. Matsuo, H. Nozaki, M. Nakayama, D. Takaoka, and M. Hiroi Three Acetylated Diterpene Diols of Verrucosane Type from the Liverwort, Mylia verrucosa. Chem. Letters 1978, 953. 

Matsuo, A., H. Nozaki, M. Nabcayama, S. Hayashi, and D. Takaoka Structure of (—)-2,9-Dihydroxyverrucosane, a Novel Carbon Skeletal Diterpenoid from the Liverwort Mylia verrucosa. Chem. Commun. 1978, 198. 

Nozaki, H., A. Matsuo, Y. Kushi, M. Nakayama, S. Hayashi, D. Takaoka, and N. Kamijo The Structure and Absolute Configuration of (—)-2p,9a-Dihydroxyverru-cosane Isolated from the Liverwort Mylia verrucosa X-Ray Analysis of the Mono-/ -bromobenzoate. J. Chem. Soc. Perkin Trans. II 1980, 763. 

Takaoka, D. Structure of Six Verrucosanes, Novel Carbon Skeletal Diterpenoids from the Liverwort, Mylia verrucosa Lindb. J. Chem. Soc. Perkin Trans I 1979, 2711. 

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