Mycophenolate Rifampicin

MYCOPHENOLATE METRONIDAZOLE, NORFLOXACIN, RIFAMPICIN Significant 1 plasma mycophenolate concentrations (>60% with rifampicin) Inhibition of metabolism of mycophenolate Avoid co-administration... 

Rifampicin reduces the levels of mycophenolic acid (the active metabolite of mycophenolate) and increases the leveis of the metabolite associated with mycophenolate adverse effects. 

A subsequent study by the same authors in 8 kidney transplant patients taking mycophenolate 750 mg to 1 g twice daily found that rifampicin 600 mg daily for 8 days decreased the AUC0.12 and peak levels of mycophenolic acid by 17.5% and 18.5%, respectively. Glucuronide levels were increased and the AUC0.12 and peak levels of the acyl glucuronide metabolite, which has been associated with an increase in mycophenolate adverse effects, was significantly increased by 193% and 121%, respectively. ... 

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