Mycophenolate mofetil disposition

Disposition and Pharmacokinetics Mycophenolate mofetil is rapidly and completely metabolized to MPA after oral or intravenous administration. MPA, in turn, is metabolized to the inactive glucuronide MPAG. The parent drug is cleared from the blood within a few minutes. The tj of MPA is 16 hours. Negligible (<1%) amounts of MPA are excreted in the urine. Most (87%) is excreted in the urine as MPAG. Plasma concentrations of MPA and MPAG are increased in patients with renal insufficiency. In early renal transplant patients (<40 days post-transplant), plasma concentrations of MPA after a single dose of mycophenolate mofetil are approximately half of those found in healthy volunteers or stable renal transplant patients. 

Naderer OJ, Dupuis RE, Heinzen EL, Wiwattanawongsa MS, Johnson MW, Smith PC. The influence of norfloxacin and metronidazole on the disposition of mycophenolate mofetil. J Clin Pharmacol (2005) 45, 219-26. 

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See also in sourсe #XX -- [ ]

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