Mycinose-containing antibiotics

The disaccharide methyl 2-0-(a-L-fucopyranosyl)-P-D-galactopyranoside. The 16-membered macrolide antibiotic chalcomycin, which contains chalcose (16) and mycinose (17) as monosaccharide subunits and the macrocyclic lactone... 

A pathway has been proposed for the biosynthetic hydroxylation and glycosylation of tylactone to give the antibiotic tylosin (contains mycinose and mycarosyl-mycaminose carbohydrate units). 

A combination of chemical and spectroscopic methods has been elegantly used to establish the complete structures of aldgamycins E and F (338), two closely related macrolide antibiotics isolated from Streptomyces lavendulae. Each antibiotic contains mycinose (6-deoxy-2,3-di-0-methyl-D-allose) and aldgarose (see p. 100) as component sugars. 

Glycosylation was effected during the preparation of the deoxytetrahydrodes-mycosin 1, a macrocyclic antibiotic containing mycinose and desosamine. ... 

---