Mutation, light-induced

Herrera, G., Urios, A., Alexandre, V, and Blanco, M., (1988). UV light induced mutability in Salmonella strains containing the limit DC or the mite AB operon evidence for a limit C function. Mutation Res. 198 9-13. 

In order to compare mutation frequency induced by 220-MeV C ions with that by low-LET radiation (electrons), Arabidopsis visible phenotype loci were chosen as follows transparent testa tt) whose seed coat is transparent because of lack of pigment glaborous gl), which have no hair on their leaves and stems and long hypocotyl hy) whose hypocotyl is longer than that of the wild type in the light condition. Mutation frequencies of tt, gl, and hy induced by carbon ions were 8- to 34-fold higher than those by electrons (Table 2). In this study, irradiation doses for the induction of mutation were determined from the RBE of carbon ions compared with that of electrons on the survival of plants, which was approximately 5. Both doses are at three-quarters of the shoulder dose of each survival curve [104]. 

Parshad, R., Taylor, W.G, Sanford, K.K., Camalier, R.F., Gantt, R. Tarone, R.E. (1980) Fluorescent light-induced chromosome damage in human IMR-90 fibroblasts role of hydrogen peroxide and related free radicals. Mutat. Res., 73, 115-124... 

Pedersen, R.A., and F. Mangia. Ultraviolet-light-induced unscheduled DNA synthesis by resting and growing mouse oocytes. Mutat. Res. 49 425-429, 1978. 

Maher, V.M., Ouellette, L.M., Curren, R.D., and McCormick, J.J. (1976) Frequency of ultraviolet light-induced mutations is higher in xeroderma pigmentosum variant cells than in normal human cells. Nature, 261, 593-595. 

Recent reports have identified the p53 genetic marker for UV-induced skin cancer (Piercell et al. 1991 Rady et al. 1992 Burns et al. 1993 Moles et al. 1993). The DNA mutations induced by UV light occur when UV radiation is absorbed by the DNA and pyrimidene photoproducts are produced. The misrepair of the photoproducts at dipyrimidine sites causes transition mutations (Mitchell et al. 1992). CC to TT transition mutations in the p53 gene have been identified as the unique molecular marker for UV-light-induced skin cancer (Brash et al. 1996) and the resulting mutation... 

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