Mutagenicity by Metabolic Activation

It is not strange, therefore, if we observe positive mutagenic responses of insects to indirect mutagens and/or carcinogens. Indeed, Drosophila has been found to respond to several kinds of indirect mutagens that require enzymatic activation. In the silkworm, the response pattern to some indirect mutagens is more or less different from that observed for Drosophila. Chemicals thus 

In short, mutation response to DMNA and AAF differed sharply between 

TABLE 11. Mutagenicity of A-Dimethylnitrosamine for Various Germ Cells 

Treatment (Mg/capita) Total number of eggs observed pe locus re locus  

TABLE 12. Reversion of Salmonella TA98 with AAF in the Presence of Silkworm Microsomes (Sm) 

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