Muscle contraction structural description

Structural Description of the Sliding Filament Model of Muscle Contraction... 

Despite the above noted correlation of phenomena, current descriptions of molecular structure and resulting function of hemoglobin and myoglobin (as well as of muscle contraction to be addressed at the molecular level in Chapter 8) proceed without consideration of the consilient mechanism. th the consilient mechanism in mind, however, a distinctive way of looking at protein structure and function materializes. The availability of so many protein crystal structures from The Protein Data Bank and, as employed in our case, the capacity to... 

A structural dilemma lies in combining a phase concept of the molecular arrangement with the molecular description of the contraction process. It is known that the movements of different myosin heads on a particular myosin thread occur asynchronously, which is evident for example, from X-ray diffraction experiments. That means that a force is generated constantly with time. The coordination of movement between every muscle cell (down to the individual actin/myosin molecule) is controlled by the excitation via the tubuli system, which is a cubosome type of membrane system, described in the previous chapter. 

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