Muscarinic cholinergic generation

Salamone, J. D., Correa, M., Carlson, B. B., Wisniecki, A., Mayorga, A. J., Nisenbaum, E., Nisenbaum, L., Felder, C. Neostriatal muscarinic receptor subtypes involved in the generation of tremulous jaw movements in rodents. Implications for cholinergic involvement in Parkinsonism, Life Sci. 2001, 68, 2579-2584. 

The first generation of cholinomimetics, such as arecoline, bethanecol and pilocarpine, were not designed for the treatment of AD and the results of the early clinical trials were consistently disappointing. In addition to their poor bioavailability and short duration of action, any therapeutic benefits were limited by their cholinergic side effects. The second generation of muscarinic... 

Antihistamines differ primarily in terms of their potency, selectivity of action, and side effects. The newer second-generation Hj blockers, loratadine and fexofenadine, for example, are more specific for Ha receptor antagonism than the older generation, which can also block cholinergic and muscarinic receptors. In addition, the... 

Tricyclic first generation antidepressants as for example imipramine and dothiepin (fig. 2) not only inhibit 5-HT and NE reuptake but also act as antagonists on histamine-1, cholinergic muscarine, adrenergic alpha and 5-HT2 receptors [26-28]. 

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