Multiscaffold libraries

Developing synthetic routes that provide skeletal diversity with multiple core scaffolds or backbone structures is an area of particular current interest. Several approaches to generating such multiscaffold libraries have been advanced. In one straightforward strategy, Schultz synthesized a 45 140-member library from multiple heterocyclic scaffolds, each having a set of functional groups in common [39]. The scaffolds were coupled as building blocks, which were then... 

Fig. 9.1-10 Small molecule modulators of stem cell differentiation. Schultz has discovered a number of small molecules that modulate stem cell differentiation from a multiscaffold library of druglike heterocycles [39] (see Fig. 9.1-6(a)).

Fig. 9.1-4 Early efforts toward multiscaffold (b) proposed squaric acid as a versatile libraries, (a) Armstrong converted an Ugi precursor to various cyclic scaffolds, multicomponent reaction product to several demonstrating several such reactions [20], linear and cyclic derivatives [19] and...

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