Multiple recognition hosts

We now can prepare, in principle, enzyme models by use of the concept of host design, where artificial enzymes are so designed as multiple recognition hosts schematically shown in Fig. 20. Although unsubstituted cyclodextrins are well known to catalyze some organic reactions such as ester hydrolysis, their catalytic activities are relatively small. Recent progress in cyclodextrin chemistry has shown that it is possible to enhance the catalytic... 

Today the most important factor seems to be the steric fit, in other words, the optimal size fit of the convex guest inside the concave binding site of the host. In such a way, a guest selection according to the size and shape of the guest molecules is possible. Most often several of the above mentioned binding forces will be effective to a different extent. The biochemical principle of multiple recognition in e.g. enzyme substrate... 

Schmidtchen, F. P. - Multiple recognition in polytopic anion hosts... 

Therefore, both hydrophobic and electrostatic interactions in aqueous solution are exploited in this specific host-guest complexation, and this provides a model for multiple recognition sites common in biological systems. 

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