Multiple intravenous bolus dosing state

P. Veng-Pederson, Model-independent method of predicting peak, trough, and mean steady-state levels in multiple intravenous bolus dosing in nonlinear pharmacokinetics. / Pharm Sci 72 1098-1100 (1983). 

But our work is still not done In order to use either Eq. 12.45 or Eq. 12.30, a value for fmax, the time to peak at steady state from our oral regimen, is needed. This is calculated from Eq. 12.7, for which we know values of the absorption and the elimination rate constants. Once the time to peak at steady state for the oral regimen is calculated, we can work our way backwards Tmax allows calculation of (Oss)orai by Eq. 12.45 or 12.30 then having a value of (Oss)orai allows Calculation of tjv by Eq. 12.44. Finally tiv can be inserted into Eq. 12.43 and the equation solved for the new multiple intravenous bolus maintenance dose, (Dm)iv-... 

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