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Multiple dosing fluctuation

Notice that Eq. 12.43 includes two different dosing intervals tjv in the numerator and Xorai in the denominator Torai is the known interval for a satisfactory oral dosing regimen. In order to control fluctuation for the new multiple intravenous bolus dosing regimen, it is necessary to calculate a smaller (shorter) value for tiv and then insert this value into the numerator of Eq. 12.43. Since this means that the intravenous bolus will be given more frequently, and since (Cave)ss should... [Pg.255]

Studies in patients and healthy subjects, given single or multiple oral doses of indometacin, found that foixl delayed and reduced peak serum indometacin levels, but fluctuations in levels were somewhat reduced. ... [Pg.147]

See other pages where Multiple dosing fluctuation is mentioned: [Pg.257]    [Pg.16]    [Pg.349]    [Pg.414]    [Pg.85]    [Pg.93]    [Pg.137]    [Pg.144]    [Pg.642]    [Pg.1171]    [Pg.1851]    [Pg.1252]    [Pg.197]    [Pg.482]    [Pg.201]    [Pg.661]    [Pg.158]    [Pg.255]    [Pg.686]    [Pg.177]    [Pg.117]   
See also in sourсe #XX -- [ Pg.16 ]



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