Multiple component condensations MCC

SCHEME 14.14 Synthesis of glycomimetics by Ugi four-component condensation. 

SCHEME 14.15 Wong s Ugi-multicomponent combinatorial synthesis of neomycin mimics. 

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As early as 1961, Ugi [55] theorized the use of multicomponent reactions for the generation of large collections of compounds and, in the following years, other related works were reported [56-58]. It was only recently, though, that the full potential of multiple component condensations (MCCs) for the generation of combinatorial libraries became apparent, due to the efforts of major pharmaceutical industries and academic research groups. 

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