Multicomponent Domino Reaction in Water

The domino process involves an aza-Morita-Baylis-Hillman/reduction sequence. A series of tosylamide-functionalized coumarin derivatives 145 were assembled with high diastereoselectivity concerning the newly created contiguous carbon centers. 

Moreover, Tu, li, and coworkers [89] presented a regioselective [4-I-2-I-1] domino cychzation for the synthesis of spiro-substituted benzo[fc]furo[3,4-e][l,4]diazepine 

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