Multi-parametric optimisation

Hit to lead and lead to candidate optimisation using multi-parametric principles. Drug Disc. World 2001, 2, 9-15. 

Note that only inputs vector U = [ut, . .., Ut+N u-i ] contain the optimisation variables where y provides the initial conditions for the states, which are the parameters in the multi-parametric programming framework. Finally, using the transformation of variables z = U + (t), Eq. (8) is converted into the mp-QF problem, as follows ... 

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