Multi-item Gamma Poisson Shrinker MGPS

The PRR is just one of several measures of disproportionality that have been used. A reporting odds ratio (ROR) can be calculated from the same 2X2 table and has been mostly used in the Netherlands. The WHO uses the Information Component (IC) and the US Food and Drugs Administration the Multi-Item Gamma Poisson Shrinker (MGPS), both of which are more complex measures based on Bayesian statistics. These measures tend to produce less extreme values than PRRs when the number of cases is very small. However, when the sensitivity, specificity and predictive power of these measures were compared using Dutch data in 2002, no important differences were found provided at least 3 cases had been reported. 

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