Multi hyphenated SFC techniques

Both flow-cell and solvent elimination SFC-FTTR are useful, in particular for thermolabile components. This hyphenated technique requires a compromise between chromatographic and spectroscopic requirements. Its use 

Principles and Characteristics Fourier-transform infrared detection in SFC is attractive because it can offer structural information about the analytes [372]. The coupling was introduced in 1983 [373]. Various approaches have been advanced  

Consequently, the major experimental options for the analyst are packed or capillary SFC, mobile phase with/without modifier and off-line or on-line mode, namely direct deposition (DD-SFC-FUR) vs. flowcell. Both small-bore packed columns and narrow-bore open-tubular columns have been used for SFC-FTIR analysis using a pressure-stable, thermostated, flow-cell or solvent elimination interfaces. 

The problems discussed above may be circumvented by eliminating the mobile phase before measuring the spectra of the eluites, as first demonstrated by Shafer et al. [379] for pSFC-FTIR. Each eluite was deposited on a moving glass plate, on which a layer of powdered KC1 or KBr had been laid down from methanol slurry for diffuse reflectance spectroscopy (SFC-DRIFTS). Solvent elimination SFC-FTIR after deposition of the eluites on to a moving ZnSe substrate is quite straightforward the window is moved to the 

As most polymers contain relatively few additives, the high resolving power of capillary SFC columns is 

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