Multi-component reactions using isatoic anhydride

Multi-component reactions using isatoic anhydride 

Isatoic anhydride can be used as a versatile synthon for the synthesis of a diverse set of molecules. The isatoic anhydride can be reacted with amines, amides, hydrazides, isothiocyanates, diketo substrates, aminoacids, amino-, thio or hydroxy anilines, as well as in a three-component reaction with aldehydes and amines to form a large set of diverse pharmacophores. 

In 1996, Borrell and co-workers published58 a two-step procedure to form pyrido[2,3-d]pyrimidines. Mont and co-workers have recently transformed this reaction to a single-step three-component reaction59. a, 3-Unsaturated carboxylic acid esters were 

The application of microwave technology to speed up chemical reactions is now an accepted and acknowledged tool among chemists. However, combining it with other methodologies such as multi-component reactions can further enhance the benefits offered by the microwaves alone. 

This chapter is a non-comprehensive summary of the available papers where microwave dielectric heating has been used in combination with multi-component reactions. The examples highlight the fabulous possibilities that can be found in the cross-section of these technologies. The numbers of papers describing the combination are still limited, but nevertheless microwave heating will have an impact in the area and most certainly, we will see an increased number of publications and increased interest in the near future. 

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Multi-component reactions using isatoic anhydride... 

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