Mucoadhesive performance

Eouani, C., et al. 2001. In-vitro comparative study of buccal mucoadhesive performance of different polymeric films. Eur J Pharm Biopharm 52 45. 

Lehr, C.M., et al. 1993. A surface energy analysis of mucoadhesion II. Prediction of mucoadhesive performance by spreading coefficients. Fur J Pharm Sci 1 19. 

Han, R.-Y. Fang, J.-Y. Sung, K.C. Hu, O.Y.P. Mucoadhesive buccal disks for novel nalbuphine prodrug controlled delivery Effect of formulation variables on drug release and mucoadhesive performance. Int. J. Pharm. 1999, 177 (2), 201-209. 

The ex vivo methods lend themselves easily for the performance of mechanistic investigations. In order to optimize selection of drug candidates prior to further clinical development, it is important to decipher the contributive roles of permeation, metabolism, efflux, and toxicity. This will then make it possible to properly channel the optimization process, for instance, by permeation enhancement, mucoadhesion, modification of the physicochemical characteristics of the drug, or even change in the route of administration in case the drug and/or formulation turns out to be too toxic. Regarding permeability studies, it is possible not only to quantify passive diffusion but also to identify and characterize (compound)-specific carrier-mediated transport routes. These tools have been used to identify and characterize the relative contribution of... 

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