Motif-based secondary structure prediction

Pattern and Motif-Based Secondary Structure Prediction... 

The key structural features predicted for the amphipathic helix by the original model (Segrest et al., 1974) enabled three laboratories to study independently how amino acid variability determined the properties of the amphipathic helix (Kanellis et al., 1980 Fukushima et al., 1980 Sparrow et al., 1981). The strategy adapted by these investigators was based, not on the primary sequence of naturally occurring apolipoproteins, but on incorporating the periodicity of the secondary structural features of the amphipathic helix motif into the sequences of the peptide analogs. 

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